5-MTHF by XYMOGEN – Bioactive Folate for Methylation Support
5-MTHF by XYMOGEN offers a focused way to add active folate to a practitioner-guided nutrition plan. This 60-capsule formula supplies Quatrefolic®, a glucosamine salt of 5-methyltetrahydrofolate, with 3,400 mcg DFE of folate in each two-capsule serving. As a bioactive folate supplement, it provides the form used in folate-dependent methylation rather than relying on the conversion steps required by folic acid. It is designed for targeted folate needs, making it a distinct choice from a multivitamin or a combination B-vitamin formula.
Key 5-MTHF Benefits
- Provides methylation support for everyday cellular and metabolic processes that use methyl groups.
- Supports healthy serum folate levels with a biologically active form of this essential B vitamin.
- Contributes to normal cell division and red blood cell support through folate's role in DNA synthesis.
- Offers nervous system support through folate-dependent pathways involved in normal brain function.
How 5-MTHF Works
Folate helps transfer small carbon units that cells use to build and maintain essential molecules. In its methylated form, it works with vitamin B12 in the conversion of homocysteine to methionine. Methionine can then contribute to the body's supply of methyl groups, which are used in many metabolic reactions. This relationship makes homocysteine metabolism support one useful aspect of folate nutrition. Folate also contributes to nucleotide production, connecting adequate intake with DNA synthesis and the normal renewal of cells.
Key Functional Ingredients Include:
- L-5-methyltetrahydrofolate: Supplies active folate to support folate status and normal homocysteine metabolism. The Quatrefolic® folate form identifies the glucosamine salt used in these capsules, rather than folic acid.
These vegetarian folate capsules use a hypromellose-and-water capsule shell. The single-nutrient approach allows a healthcare professional to consider folate separately from other B vitamins when planning a regimen. Review any multivitamin or prenatal supplement alongside this product so your daily folate intake fits your individual needs.
5-MTHF Is Formulated For
- Adults whose healthcare professional recommends active folate to complement dietary intake.
- People seeking a dedicated folate option within a personalized methylation or cardiovascular nutrition plan.
- Adults who prefer a capsule and want targeted folate support rather than another broad B-complex formula.
Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner before starting a new supplement. Ready to find the right fit? Access Now to schedule a consultation with our licensed wellness professionals at Holistic Health Partners, led by Carolyn Mulally BS, RN, HN-BC. You may also wish to explore our Methylation Support collection.
Recommendation: Take one to two capsules daily, or as directed by your healthcare professional.
Serving Size: 2 Capsules
Servings Per Container: 30
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt)S1 ... 3,400 mcg DFE
S1. Quatrefolic® is a registered trademark of Gnosis S.p.A. Produced under U.S. patent 7,947,662.
Other Ingredients: Microcrystalline cellulose, capsule (hypromellose and water), stearic acid, magnesium stearate, and silica.
Formulated to exclude: Animal Products, Corn, Dairy, Egg, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, Yeast.
Storage: Keep closed in a cool, dry place out of reach of children.
Frequently Asked Questions About 5-MTHF
What are the benefits of 5-MTHF?
5-MTHF provides active folate for methylation, healthy folate levels, and normal cell division. Folate is needed for DNA synthesis and normal red blood cell production, and its methylated form participates in homocysteine metabolism. This formula supplies 3,400 mcg DFE per two-capsule serving as Quatrefolic®. Its focused composition can be useful when your healthcare professional wants to address folate intake separately from the other nutrients in a multivitamin or B-complex.
Who should take 5-MTHF?
Adults whose healthcare professional recommends supplemental active folate may consider this formula. It can fit a targeted nutrition plan when dietary intake or individual needs call for additional folate. Bring your current supplement list to that discussion, especially if you already take a multivitamin, prenatal formula, or B-complex. If you are pregnant, planning pregnancy, breastfeeding, or taking medication, obtain individualized guidance before use so the folate amount and the rest of your nutrition plan are appropriate.
Are there any side effects of taking 5-MTHF?
Individual responses can vary, and a bioactive nutrient is not automatically suitable for everyone. Follow the manufacturer’s instruction to consult your healthcare professional before use, particularly if you take medication and need potential interactions reviewed. Check the complete ingredient list if you have sensitivities. If you notice an unexpected response after starting the capsules, stop use and seek professional advice rather than increasing the amount. Do not use the product if its tamper seal is damaged.
How does 5-MTHF support overall health?
Folate supports processes that many tissues rely on, including DNA synthesis, normal cell renewal, and methyl-group transfer. These roles connect adequate folate nutrition with normal blood cell formation and nervous system function. In methylation pathways, active folate works alongside vitamin B12 rather than acting alone. Use 5-MTHF as one part of a balanced nutrition plan that considers your diet, other supplements, and individual needs; a dedicated folate capsule does not replace the full range of nutrients your body requires.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
