Methylation Bundle by Thorne – Methylation Support Supplement Bundle
Methylation Bundle by Thorne combines three capsule supplements: Methyl-Guard Plus, Magnesium CitraMate and D-5,000. This methylation support combination pairs active B vitamins and betaine with magnesium and vitamin D3, rather than putting every nutrient into one capsule.
Thorne currently calls this BUN016 combination Methylation Stack. It contains Methyl-Guard Plus (90 capsules), Magnesium CitraMate (90 capsules) and D-5,000 (60 capsules); each bottle has its own directions and serving size.
Key Methylation Bundle Benefits
- Supports normal methylation by supplying nutrients that help transfer the small chemical groups used throughout everyday cellular metabolism.
- Helps maintain healthy homocysteine metabolism with folate, vitamin B12 and betaine working in complementary nutrient pathways.
- Supports normal muscle and nerve function with magnesium, while vitamin D helps the body absorb calcium for healthy bones.
How Methylation Bundle Works
Methylation moves small chemical units called methyl groups between molecules. Folate and vitamin B12 work together to recycle homocysteine into methionine, an amino acid the body uses to make an important methyl donor. Betaine supports a complementary recycling pathway. The B2 and B6 in Methyl-Guard Plus assist nutrient-processing enzymes, including enzymes involved in homocysteine metabolism.
Magnesium supports the enzymes that help cells use energy, as well as normal nerve and muscle signaling. Vitamin D supports calcium absorption and bone maintenance. These nutrients have complementary nutritional roles; the bundle is not a genetic test or a substitute for an individualized assessment of nutrient needs.
Key Functional Ingredients Include:
- Betaine Anhydrous (Trimethylglycine): Supplies methyl groups used to recycle homocysteine into methionine, particularly in the liver and kidneys. This supports the body's normal methyl-group supply and complements the folate-dependent pathway, helping explain betaine's place in a methylation-focused formula.
- Folate (L-5-Methyltetrahydrofolate): Carries single-carbon units used in normal cellular metabolism. Its methylated form works with vitamin B12 to recycle homocysteine, connecting folate to the body's methylation cycle. Folate also contributes to making the building blocks of DNA needed for normal cell division.
- Vitamin B12 (as Methylcobalamin): Helps an enzyme transfer a methyl group from folate to homocysteine to form methionine. This links vitamin B12 directly to the methylation cycle and helps keep folate available for other essential cellular tasks, including normal DNA production.
- Magnesium: Helps enzymes use cellular energy and supports the movement of minerals involved in nerve signals and muscle contraction. Magnesium CitraMate supplies citrate and malate forms, providing nutritional support for these everyday functions alongside the bundle's methylation-focused vitamins.
- Vitamin D3: Supports calcium absorption from the digestive tract and helps maintain the mineral balance needed for healthy bones. It also contributes to normal muscle and immune function, adding bone and musculoskeletal support to this three-product combination.
Methylation Bundle Is Formulated For
- Adults seeking practitioner-guided nutritional support for normal methylation and homocysteine metabolism.
- Adults whose practitioner recommends combining active B vitamins and betaine with magnesium and higher-potency vitamin D.
D-5,000 supplies more vitamin D than the general adult daily upper limit of 4,000 IU. Have your practitioner review your total vitamin D intake and monitoring needs before using this bundle.
Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner before starting a new supplement. Ready to find the right fit? Access Now to schedule a consultation with our licensed wellness professionals at Holistic Health Partners, led by Carolyn Mulally BS, RN, HN-BC. You may also wish to explore our other Cardiovascular Supplements and Thorne collections.
Methyl-Guard Plus — 90 capsules
Recommendation: Take 1-3 capsules daily or as recommended by your health-care practitioner.
Serving Size: Three Capsules
Servings Per Container: 30
Riboflavin (as Riboflavin 5’-Phosphate Sodium) ... 90 mg
Vitamin B6 (as Pyridoxal 5’-Phosphate) ... 45 mg
Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) ... 5 mg DFE
Vitamin B12 (as Methylcobalamin) ... 3 mg
Betaine Anhydrous (Trimethylglycine) ... 1.8 g
*Daily Value (DV) not established.
†This product uses Gnosis S.p.A.’s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A.
Other Ingredients: Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate.
Does Not Contain: Gluten
Storage: Store tightly sealed in a cool, dry place.
TAMPER EVIDENT: Use only if bottle is sealed.
ALLERGY WARNING: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY: If pregnant, consult your health-care practitioner before using this product.
INTERACTIONS (manufacturer statement): 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
Magnesium CitraMate — 90 capsules
Recommendation: Take 1 capsule one to three times daily or as recommended by your health-care practitioner.
Serving Size: One Capsule
Servings Per Container: 90
Magnesium (55 mg as Magnesium Citrate and 80 mg as Albion® DiMagnesium Malate)† ... 135 mg
Daily Value (DV)
†This product uses Albion’s DiMagnesium Malate. Albion is a registered trademark of Albion International, Inc.
Other Ingredients: Hypromellose (derived from cellulose) capsule, Medium Chain Triglyceride Oil.
Does Not Contain: Gluten
Storage: Store tightly sealed in a cool, dry place.
TAMPER EVIDENT: Use only if bottle is sealed.
ALLERGY WARNING: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY: If pregnant, consult your health-care practitioner before using this product.
INTERACTIONS (manufacturer statement): There are no known adverse interactions or contraindications at publication date.
ADDITIONAL WARNINGS: Gas, bloating, or diarrhea may occur in some individuals taking magnesium supplements. This can occur at varying amounts depending on the individual and resolves when the amount is reduced.
D-5,000 — 60 capsules
Recommendation: Take 1 capsule daily or as recommended by your health-care practitioner.
Serving Size: One Capsule
Servings Per Container: 60
Vitamin D (as Vitamin D3) (5,000 IU) ... 125 mcg
Daily Value (DV)
Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide, Vitamin E (d-Alpha Tocopheryl).
Does Not Contain: Gluten
Storage: Store tightly sealed in a cool, dry place.
TAMPER EVIDENT: Use only if bottle is sealed.
ALLERGY WARNING: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY: If pregnant, consult your health-care practitioner before using this product.
INTERACTIONS (manufacturer statement): There are no known adverse interactions or contraindications at publication date.
Additional clinical cautions: The manufacturer interaction statements do not replace a medication review. Magnesium can interact with certain antibiotics and oral bisphosphonates; vitamin D can interact with thiazide diuretics and other medicines. Excess vitamin D can raise blood calcium, and excessive supplemental vitamin B6 can injure sensory nerves. Review overlapping supplements and medicines with your practitioner, especially before long-term use.
Frequently Asked Questions About Methylation Bundle
What are the benefits of Methylation Bundle?
Methylation Bundle combines Methyl-Guard Plus, Magnesium CitraMate and D-5,000 to support normal methylation, homocysteine metabolism, muscle and nerve function, and bone health. Betaine, folate and vitamin B12 support methyl-group transfer; magnesium and vitamin D contribute complementary nutritional support.
Who should take Methylation Bundle?
This combination is intended for adults whose practitioner recommends methylation-supportive B vitamins and betaine together with magnesium and higher-potency vitamin D. D-5,000 exceeds the general adult vitamin D upper limit, so total intake and monitoring should be reviewed. The bundle is not a substitute for evaluating a suspected nutrient deficiency or genetic concern.
Are there any side effects of taking Methylation Bundle?
The magnesium component can cause gas, bloating or diarrhea. Thorne contraindicates the components for anyone with hypersensitivity to their ingredients and advises consulting a health-care practitioner if pregnant. Methyl-Guard Plus is not recommended during methotrexate cancer therapy. Other methotrexate use still requires the prescriber’s review. Excess vitamin D can raise blood calcium; excessive supplemental B6 can injure sensory nerves. Magnesium can interact with certain antibiotics and oral bisphosphonates, and vitamin D can interact with thiazide diuretics and other medicines. Use only sealed bottles and review medicines and overlapping supplements before starting.
How does Methylation Bundle support overall health?
Folate, vitamin B12 and betaine help keep methyl-group transfer and homocysteine recycling functioning normally. Magnesium supports cellular energy use and nerve and muscle signaling, while vitamin D supports calcium absorption and normal immune function. The three separate formulas complement these everyday processes without replacing a balanced diet.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
