SAMe

SAMe by Designs for Health – Methylation Support Capsules

SAMe capsules by Designs for Health combine stabilized S-adenosyl-L-methionine with vitamin B6, methylated folate, and methylcobalamin for methylation support. The vegetarian capsules use acid-resistant encapsulation designed to withstand the stomach environment, distinguishing this formula from SAMe-only supplements.

Key SAMe Benefits

• Supports methylation by supplying a methyl donor used in normal protein, lipid, and DNA processing throughout the body.
• Provides B-vitamin cofactors that help maintain normal homocysteine metabolism and recycle methionine within the methylation cycle.
• Supports normal neurotransmitter production with vitamin B6, while vitamin B12 contributes to healthy nervous system function.

How SAMe Works

Methylation transfers small chemical units called methyl groups between molecules. These transfers help cells process DNA, proteins, and membrane fats as part of normal cellular metabolism. SAMe supplies methyl groups, while folate and vitamin B12 help recycle homocysteine back to methionine, the amino acid used to make SAMe. Vitamin B6 supports a separate route that converts homocysteine toward cysteine.

Key Functional Ingredients Include:

• SAMe: Supplies methyl groups that cells use to modify DNA, proteins, and membrane fats. This everyday process helps regulate gene activity and normal cellular function. SAMe participates in the interconnected pathways that link methylation with the production of cysteine, a building block for glutathione.
• Vitamin B-6 (as Pyridoxal-5-Phosphate): Helps enzymes process amino acids and make neurotransmitters, the chemical messengers used by nerve cells. It also supports the pathway that converts homocysteine toward cysteine, complementing the folate- and B12-dependent recycling pathway in this formula.
• Folate (as Quatrefolic® [6S]-5-Methyltetrahydrofolate, glucosamine salt): Provides methylfolate, which works with vitamin B12 to help convert homocysteine back to methionine. Methionine can then be used to make SAMe. Folate also contributes to normal DNA production and cell division, connecting this nutrient to everyday cellular maintenance.
• Vitamin B-12 (as Methylcobalamin): Supports the enzyme that works with methylfolate to recycle homocysteine into methionine, helping sustain the methylation cycle. Vitamin B12 is also needed for normal nerve function and healthy red blood cell formation; methylcobalamin is an active coenzyme form.

SAMe Is Formulated For

• Individuals whose health-care practitioner recommends SAMe with B-vitamin cofactors for methylation support.
• Those seeking a vegetarian formula with methylated B vitamins alongside stabilized SAMe.

Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner before starting a new supplement. Ready to find the right fit? Access Now to schedule a consultation with our licensed wellness professionals at Holistic Health Partners, led by Carolyn Mulally BS, RN, HN-BC. You may also wish to explore our other Designs For Health collection.

Recommendation: Take 1 capsule per day, preferably on an empty stomach, or as directed by your health-care practitioner.

Serving Size: 1 capsule (both sizes)
Servings Per Container: 30-capsule bottle: 30; 90-capsule bottle: Not stated on the manufacturer's label

Other Ingredients: Cellulose (capsule), microcrystalline cellulose, vegetable stearate.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.