SAMethylate Plus™ by Biotics Research – Methylation Support
SAMethylate Plus™ combines SAMe with B vitamins, amino acid building blocks, and related nutrients for methylation support. SAMe occurs naturally in human cells and participates in the transfer of methyl groups, a basic process involved in normal cellular function. This Biotics Research supplement supplies 200 mg of SAMe per two-capsule serving alongside folate, vitamin B12, vitamin B6, choline, L-methionine, and trimethylglycine. The current manufacturer presentation contains 120 capsules; the facts below describe that formulation.
Key SAMethylate Plus™ Benefits
- Provides a SAMe supplement with complementary nutrients involved in normal methyl-group metabolism.
- Combines methylfolate and methylcobalamin with vitamin B6 to support interconnected nutrient pathways rather than supplying SAMe alone.
- Offers targeted cellular nutrition support in an acid resistant vegetarian capsule shell, with a manufacturer-labeled gluten- and dairy-free formula.
How SAMethylate Plus™ Works
Methylation transfers a small chemical group from a donor to another molecule. SAMe is a principal methyl donor in reactions involving proteins, phospholipids, and DNA. After donating its methyl group, it enters pathways that connect with methionine recycling and sulfur-amino-acid metabolism. Folate and vitamin B12 participate in the recycling pathway, while vitamin B6 serves as a cofactor in a related pathway leading toward cysteine. These are normal biochemical roles, not a promise of a particular clinical outcome or a reason to replace prescribed care.
Key Functional Ingredients Include:
- SAMe: A naturally occurring methyl donor involved in normal cellular metabolism. Its biochemical role explains its inclusion without establishing a specific response to this combination.
- Folate and vitamin B12: Supplied as calcium methylfolate and methylcobalamin, these nutrients participate in methionine recycling and complement the formula's methyl donor.
- Vitamin B6: Provided as pyridoxal-5-phosphate, a cofactor used in amino acid metabolism.
- L-Methionine, choline, and trimethylglycine: Provide related building blocks and nutrients involved in methyl-group metabolism. Trimethylglycine is also known as betaine.
- Superoxide Dismutase and Catalase: Vegetable-culture components included in the formula; the label identifies their amounts without establishing an oral antioxidant benefit.
The gluten- and dairy-free supplement uses a vegetable culture described in the footnote below. Review the complete excipient list and cautions, particularly when combining supplements or medications. The capsule's acid resistant shell is a formulation feature, not a guarantee of absorption or results.
SAMethylate Plus™ Is Formulated For
- Adults discussing daily methylation support with a healthcare professional.
- People seeking SAMe together with selected B vitamins and related metabolic nutrients.
- Individuals who want a targeted formula and can follow its specific interaction and suitability cautions.
Supplements support your health but do not replace a balanced diet. Always check with your healthcare practitioner before starting a new supplement. Ready to find the right fit? Access Now to schedule a consultation with our licensed wellness professionals at Holistic Health Partners, led by Carolyn Mulally BS, RN, HN-BC. You may also wish to explore our other Methylation Support, and Mood collections.
Recommendation: Two (2) capsules each day as a dietary supplement or as otherwise directed by a healthcare professional.
Serving Size: 2 Capsules
Servings Per Container: Not stated on the manufacturer's label.
Vitamin B6 (as pyridoxal-5-phosphate) ... 5 mg
Folate ... 170 mcg DFE
(100 mcg calcium methylfolate)
Vitamin B12 (as methylcobalamin) ... 20 mcg
Choline (as choline bitartrate) ... 25 mg
SAMe (S-Adenosyl-L-Methionine disulfate p-toluenesulfonate) ... 200 mg *
L-Methionine ... 50 mg *
Trimethylglycine ... 25 mg *
Superoxide Dismutase (from vegetable culture †) ... 12.5 mcg *
Catalase (from vegetable culture †) ... 12.5 mcg *
* Daily Value not established
† Specially grown, biologically active vegetable culture (from organic peas, lentils, and/or chickpeas) containing naturally associated phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme factors.
Other Ingredients: Acid resistant vegetarian capsule shell (cellulose and water), cellulose, rice bran wax, silica and magnesium stearate (vegetable source).
Does Not Contain: This product is gluten and dairy free.
Storage: KEEP LID TIGHTLY CLOSED AFTER OPENING
Store in a cool, dry area.
KEEP OUT OF REACH OF CHILDREN
Sealed with an imprinted safety seal for your protection.
Frequently Asked Questions About SAMethylate Plus™
What are the benefits of SAMethylate Plus™?
SAMethylate Plus™ supplies SAMe and complementary nutrients involved in normal methylation and amino acid metabolism. Its two-capsule serving provides 200 mg of SAMe with vitamin B6, folate, vitamin B12, choline, L-methionine, and trimethylglycine. These ingredients have related nutritional roles, but the formula is not a substitute for a balanced diet or prescribed treatment. A practitioner can help determine whether this targeted combination fits your needs and existing supplement routine.
Who should consider SAMethylate Plus™?
Adults interested in targeted methylation nutrition can discuss this formula with their healthcare professional. It may be an option when the combination of SAMe and supporting nutrients fits an individualized plan, rather than a reason to add several overlapping products. Pregnant or lactating women should consult their physician before use, and the label identifies important medication and health-condition restrictions. Review the complete ingredients and cautions before deciding whether this product is appropriate. Use Access Now to arrange your consultation and receive clinic access guidance and any required code before ordering.
Are there side effects or cautions with SAMethylate Plus™?
This product is not appropriate for everyone. The manufacturer instructs users to avoid it when taking monoamine oxidase inhibitors or herbs or supplements with serotonergic properties, and to avoid it in people with Parkinson’s disease. Pregnant or lactating women should consult their physician before use. These cautions mean that a medication and supplement review matters; do not assume compatibility because the product supplies nutrients. Ask your healthcare professional about individual tolerability and any unexpected symptoms.
How does SAMethylate Plus™ fit into an overall wellness routine?
Use the current manufacturer directions: two capsules each day as a dietary supplement, or as otherwise directed by a healthcare professional. Pair targeted supplementation with a balanced diet and an individualized wellness plan rather than expecting one product to meet every nutritional need. The current manufacturer bottle contains 120 capsules, and its label uses a two-capsule serving. Keep the lid tightly closed after opening, store in a cool, dry area, and keep it out of reach of children.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
