Ortho Molecular Products - CDG EstroDIM- 60ct

CDG EstroDIM - 60 CT

Ortho Molecular Products

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CDG EstroDIM - 60 CT by Ortho Molecular Products

CDG EstroDIM by Ortho Molecular Products is a targeted hormone supplement that combines the synergistic effects of Indole-3-carbinol (I3C) and Diindolylmethane (DIM) to support proper estrogen metabolism.* Additionally, the formula includes Calcium D-Glucarate, which aids in detoxifying foreign molecules, estrogens, and fat-soluble toxins, while also providing cellular antioxidant support for DNA stability.*

Who May Take CDG EstroDIM – 60 CT?

You may consider taking CDG EstroDIM – 60 CT if your goals include:

  • maintaining healthy estrogen levels within normal range*
  • supporting your breast and prostate health*
  • healthy aging*

What May CDG EstroDIM – 60 CT by Ortho Molecular Products Support?

Ortho Molecular Products CDG EstroDIM – 60 CT may:

  • support proper estrogen synthesis, metabolism, and detoxification*
  • help maintain hormonal balance and promote healthy aging*
  • provide antioxidant support for cellular health and DNA stability*

Supplements may support your health but do not replace a balanced diet. If in doubt of a new supplement, consult your healthcare provider. Book a FREE consultation with a medical advisor for more information about CDG EstroDIM 60c.

Recommendation:
Ortho Molecular Products suggests taking 2 CDG EstroDIM capsules taken one to two times per day or as recommended by your health care professional.

Serving Size: 2 Capsules
Servings Per Container: 30

Amount Per Serving:
Vitamin E (from 50 IU d-Alpha Tocopherol Succinate USP) 33.5 mg
Calcium (as Calcium D-Glucarate USP) 120 mg
Calcium D-Glucarate USP 1 g
Dietary Indoles 300 mg
(Total Indole Blend containing
Indole-3-Carbinol ( I3C, 200 mg input) and
Diindolylmethane (DIM, 100 mg input)

Other Ingredients: Natural Vegetable Capsules, Magnesium Stearate, Silicon Dioxide, and Stearic Acid

Caution: Do not consume this DIM estrogen product if you are pregnant or nursing.

 

References:

  1. Yuan, F., et al. (1999). Anti-estrogenic activities of indole-3-carbinol in cervical cells: Implication for prevention of cervical cancer. Anticancer Research, 19(3A), 1673–1680.
  2. Frydoonfar, H. R., McGrath, D. R., & Spigelman, A. D. (2003). The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line. ANZ Journal of Surgery, 73(3), 154–156.
  3. Chinni, S. R., Li, Y., Upadhyay, S., Koppolu, P. K., & Sarkar, F. H. (2001). Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest, and apoptosis in prostate cancer cells. Oncogene, 20(23), 29236.
  4. Zhang, J., et al. (2003). Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells. Cancer.
  5. Miller, K. (2003). Estrogen and DNA damage: The silent source of breast cancer? J Natl Cancer Inst, 95(2), 100–102.
  6. Auborn, K. J., Fan, S., et al. (2003). Indole-3-carbinol is a negative regulator of estrogen. Journal of Nutrition, 133(7 Suppl), 2470S–2475S.
  7. McAlindon, T. E., et al. (2001). Indole-3-carbinol in women with SLE: Effect on estrogen metabolism and disease activity. Lupus, 10(11), 779–783.
  8. Meng, Q., et al. (2000). Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signaling in human tumor cells. Journal of Nutrition, 130(12), 2927–2931.
  9. Meng, Q., Qi, M., et al. (2000). Suppression of breast cancer invasion and migration by indole-3-carbinol: Associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. Journal of Molecular Medicine, 78(3), 155–165.
  10. Lee, I. J., Han, F., Baek, J., Hisatsune, A., & Kim, K. C. (2004). Inhibition of MUC1 expression by indole-3-carbinol. International Journal of Cancer, 109(6), 810–816.
  11. Brandi, G., et al. (2003). A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines. Cancer Research, 63(14), 4028–4036.
  12. Wong, G. Y., Bradlow, L., et al. (1997). Dose-ranging study of indole-3-carbinol for breast cancer prevention. Journal of Cellular Biochemistry Supplement, 28-29, 111–116.
  13. Bradlow, H. L., Michnovicz, J. J., et al. (1994). Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiology, Biomarkers & Prevention, 3(7), 591–595.
  14. Chinni, S. R., & Sarkar, F. H. (2002). Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells. Clinical Cancer Research, 8(4), 1228–1236.
  15. Leibelt, D. A., et al. (2003). Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3’-diindolylmethane in sprague-dawley rats. Toxicological Sciences, 74(1), 10–21. https://doi.org/10.1093/toxsci/kfg121.
  16. Ashok, B. T. (2001). Abrogation of estrogen-mediated cellular and biochemical effects by indole-3-carbinol. Nutrition and Cancer, 41(1–2), 180–187.
  17. Firestone, G. L., & Bjeldanes, L. F. (2003). Indole-3-carbinol and 3,3’-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions. Journal of Nutrition, 133(7 Suppl), 2448S–2455S.
  18. Hong, C., Firestone, G. L., & Bjeldanes, L. F. (2002). Bcl-2 family-mediated apoptotic effects of 3,3’-diindolylmethane (DIM) in human breast cancer cells. Biochemical Pharmacology, 63(6), 1085–1097.
  19. Nachshon-Kedmi, M., Yannai, S., Haj, A., & Fares, F. A. (2003). Indole-3-carbinol and 3,3’-diindolylmethane induce apoptosis in human prostate cancer cells. Food and Chemical Toxicology, 41(6), 745–752.
  20. Hanausek, M., Walaszek, Z., & Slaga, T. J. (2003). Detoxifying cancer-causing agents to prevent cancer. Integrative Cancer Therapies, 2(2), 139–144.
  21. Singh, J., & Gupta, K. P. (2003). Calcium glucarate prevents tumor formation in mouse skin. Biomedical and Environmental Sciences, 16(1), 9–16.
  22. (2002). Calcium-D-glucarate. Alternative Medicine Review, 7(4), 336–339.
  23. Walaszek, Z., Szemraj, J., et al. (1997). Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detection and Prevention, 21(2), 178–190.